So I initially jumped the gun on this one, but after reviewing the FAQ, I found this:
Q: When a character is removed from play, and counts as defeated, what happens with abilities like Avoid Defeat, or Self Destruct?
A: The character is removed from play, so it cannot take advantage of any effect that would prevent it from being defeated, however, other effects that trigger when a character is defeated, like Self-Destruct, would still occur.
So if the Tactics Broker chooses a drone, the self-destruct happens, but the save doesn't.
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